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The ideal pharmacogenomic laboratory information technology infrastruc ture in Figure 5.1 only hints at the challenges associated with the knowl edge management process described in 4. Every IT installation has issues of reliability, scalability, growth, and performance that limit the knowledge management process. For example, highly reliable installations tend to be based on long-established practices, hardware, and software. However, these older or legacy systems tend to lack the performance of the newest systems. Similarly, systems that are highly reliable in small installa tions may not scale readily without major revision in the underlying infra structure. Furthermore, there are often challenges related to integration, the need for additional IT capacity, from processing power and data stor age to connectivity, and a need for applications and architectures opti mized for biotech work. Implementing an integrated IT infrastructure capable of supporting a pharmacogenic laboratory requires more than a collection of servers, large hard drives, a network, and the associated cables and electronics. The physical ergonomic and virtual interface environments must complement each other, and the degree to which these and other components are inte grated and available as a secure, collaborative environment de ne the us ability and effectiveness of the system. In addition to hardware and software tools, technical personnel must be available to operate, maintain, and upgrade the system on a regular basis. Few IT systems in biotech offer seamless integration of data because of multiple standards or because of holes in the knowledge management process. For example, many databases used in pharmacogenomic research

Some introspection is in order here. If you are selling goods, you need to give some thought to which of the ve essential contractual terms parties, price, quantity, time, and place of performance are most subject to dispute in your line of work. You need to make sure that your sales forms are very speci c as to these terms the rst time around with a new customer. A simple note in the Memo portion of the form, such as the one shown in Figure 33-3, does the trick.

(~)].

(5.13)

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So Ell does not not have any independent degrees of freedom and should not be quantized. The displacement vector D == E + 41TP, however, is transverse. Thus, in the present case, D and B, rather than E and B, are the right pair of field vectors that contain only the truly independent degrees of freedom of the field, and they are what we should use in the canonical quantization scheme. Rewriting Maxwell equations in terms of D and B, we find that

After you have dealt with the parties a few times, you establish a course of dealings and course of performance, which give you a certain comfort level. But prior to this point, QuickBooks gives you a lot of exibility in customizing your sales forms and purchase orders to add additional information about your contractual terms. Reading s 14 and 15, which deal with the subject of setting up sales forms, may save you time, grief, and legal fees.

(5.14) (5.15)

and development use proprietary formats Even when data are in a recog nizable format, there must be interfaces between applications and data bases to provide the logical connectivity for communication through the network infrastructure In addition, few laboratories or medical facilities provide the degree of connectivity suggested by the lab in Figure 51 For example, less than 5 percent of hospitals in the United States have a full electronic medical record (EMR) and many of them offer only summary information Fur thermore, these systems typically require researchers to learn several ar cane languages and procedures to access all data that may be relevant to a given patient research project,, and the results of clinical studies may be maintained in separate databases that aren t connected to the main hospi tal network.

- 41T(p 1\ V)8(r),

Figure 33-3: Adding the simple notation shown in the Memo eld can save second-guessing and potential litigation later.

(5.16) (5.17)

2To obtain (5.13) from (5.5), just solve the reciprocal space version of (5.5), which yields ell(k) -41T(k p)/k and invert:

There is often little extra storage or computational capacity in biotech IT infrastructures, owing to the kinds of problems addressed by biotech re searchers and the general nature of computing As the study of the struc ture and function of proteins (proteomics) eclipses that of relatively simple genetic sequences (genomics), the computational complexity and data in volved in the computations will increase by several orders of magnitude For example, while there are perhaps only about 35,000 genes in the hu man genome, these genes code for more than a million proteins Under standing the normal function of these proteins and their roles in disease will require supercomputer power, high-bandwidth network and Internet connectivity, and a seamless, secure, collaborative environment Providing security isn t simply a prudent step, but a legal requirement, as with the Health Insurance Portability and Accountability Act (HIPAA), which became effective in April of 2003.

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