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56 (see Watson & Tellegen, 1999, Table 1) Thus, the bipolarity of this dimension already is readily apparent in raw, uncorrected data, as we already observed in our own Table 141 (weighted mean r = 50) In contrast, measures of High Positive Affect and High Negative Affect had raw correlations ranging from 18 to 36, with a median value of 25; correcting them for measurement error yielded latent correlations ranging from 43 to 58 (Mdn = 46) More generally, analyses of this issue have established that controlling for measurement error can transform (a) low correlations into moderate correlations and (b) strong correlations into very strong correlations, but that it will not turn (c) low correlations into strong correlations (see Watson & Tellegen, 1999).

On the basis of these data, we can conclude that measurement error exerts only a moderate in uence on mood ratings, and that raw, uncorrected correlations do not yield highly distorted or misleading results This conclusion is unsurprising once one understands how these correlations are corrected for measurement error; we therefore will present a brief discussion of this topic Recent analyses of this issue (eg,.

bene ts from AZT proved to be elusive, in part because of the ability of HIV to develop resistance to individual antiretroviral agents (Larder & Kemp, 1989) Further, the use of AZT was frequently associated with dose-limiting side effects such as anemia (Richman et al, 1987), and in many patients its prolonged use was not well-tolerated In subsequent years, the ef cacy of sequencing AZT monotherapy with additional drug agents was explored With aggressive early HIV management, patients who had already received AZT and were later switched to other antiretrovirals were shown to experience better clinical outcomes (Hammer et al, 1997) This monotherapy approach to treatment remained the standard of care up until the mid-1990s, but typically provided only transient bene ts, along with a host of toxic side effects.

Perrig, W J, & Hofer, D (1989) Sensory and conceptual representations in memory: Motor images that cannot be imaged Psychological Research, 51, 201 207 Prinz, W (1997) Perception and action planning European Journal of Cognitive Psychology, 9, 129 154 Prinz, W (1998) Die reaktion als willenshandlung Psychologische Rundschau, 49(1), 10 20 Rosenbaum, D A, Hindorff, V, & Munro, E M (1987) Scheduling and programming of rapid finger sequences: Tests and elaborations of the hierarchical editor model Journal of Experimental Psychology: Human Perception and Performance, 13, 193 203 Rubinstein, S L (1964) Grundlagen der allgemeinen Psychologie Berlin: Verlag der Wissenschaften Rubinstein, S L (1984) Grundlagen der allgemeinen psychologie (10 Aufl) Berlin, Germany: Volk und Wissen Sackett, R S (1935) The relationship between amount of symbolic rehearsal and retention of a maze habit Journal of General Psychology, 13, 113 128 Saltzman, E (1979) Levels of sensorimotor representation.

Journal of Mathematical Psychology, 20, 91 163 Schack, T (1997) ngstliche sch ler im sport: Interventionsverfahren zur entwicklung der handlumgskontrolle Schorndorf, Germany: Hofmann Schack, T (2000) Experimental studies on the speed of information processing in sports-related memory Journal of Sport and Exercise Psychology, 22, 94 Schack, T (2002) Zur kognitiven architektur von bewegungshandlungen: Modelltheoretischer zugang und experimentelle untersuchungen Unver ff Habil, Psychologisches Institut, Deutsche Sporthochschule, K ln, Germany Schack, T (2003) The relationship between motor representation and biomechanical parameters in complex movements: Towards an integrative perspective of movement science European Journal of Sportscience, 3(2), 1 13 Schack, T (2004a) The cognitive architecture of complex movement International Journal of Sport and Exercise Psychology, 2(4), 403 438 Schack, T (2004b) Knowledge and performance in action Journal of Knowledge Management, 8(4), 38 53 Schack, T, & Bar-Eli, M (in press) Psychological factors in technical preparation In B Blumenstein & R.

It was within the context of limited treatment options and bleak health prospects that two nearly simultaneous medical breakthroughs occurred The rst was the development of a diagnostic test to quantify levels of HIV RNA or viral load in the blood plasma of infected individuals Although CD4 counts provided useful information about the impact of HIV on immune functioning, the ability to measure viral load provided a more precise tool for tracking progression of viral replication and assessing the impact of therapeutic medications, and led to a greater appreciation of the high HIV burden in infected persons from the onset of the illness (Ho et al, 1995) The second major breakthrough was the discovery of protease inhibitors, a new class of drugs that, when used in combination with two or more new or existing antiretrovirals, could target HIV at multiple points in the replication cycle.